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KMID : 0364019930260100743
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Korean Journal of Thoracic and Cardiovascular Surgery
1993 Volume.26 No. 10 p.743 ~ p.748
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Considerations in Relationship of Open Heart surgery & Thyroid Hormone Changes
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차경태
홍민수/허용/안욱수/김병열/이정호/현진희
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Abstract
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Alterations in thyroid function test results are frequently seen in patients with nonthyroidal illness & correlate with the severity of the illness & prognosis. We studied thyroid hormone changes in 14 patients received cardiopulmonary
bypass(CPB).
All
patients were biochemical euthyroidism preoperatively.
TSH(Thyroid Stimulating Hormone) level reached its nadir(0.46*0.11 ulU/ml, p<0.0005) at 12 hours after the start of CPB & showed elevating pattern to the preoperative level thereafter. FT4(Free Thyroxine) reached to its nadir(10.16*1.17 pmol/L.
p<0.01)
at POD (Post Operative Day) #4 & reached to the preoperative level at POD #7. Mean serum TSH & FT4 concentration were within normal limits(P>0.25) during CPB & thereafter. TT3(Total Triiodothyronine) reached to its nadir(38.6 8.4 mg/dl, P<0.001)
at
30
minutes after the start of CPB & remained low(P<0.05) throughout the study period.
The patients whose recovery was uneventful(Group I) had higher serum TSH, TT3 levels(P<0.05) than who had complications or died(Group II). Group I showed the elevating pattern of TSH, TT3 at POD #4, but Group II failed to show such elevating
pattern. In
Group I, FT4 was within normal limits (P>0.5) throughout the study period, and also within normal limits(P>0.1) in Group II. (Korean J Thoracic Cardiovas Surg 1993;26:743-8)
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